(6S)-Calcium Folinate / Calcium Levofolinate

Chemical division

Formula

CERBIOS - PHARMA SA
CAS number: 80433-71-2

 

Synonyms

(6S)-Calcium Folinate
6S)-N5-Formyl-5,6,7,8-tetrahydrofolic acid
Levoleucovorin
Levoleucovorin Calcium
Calcium (6S)-Folinate

 

Background and use

(6S)-Calcium Folinate is the isomerically pure form of the (6RS)-mixture. It is the biologically active form, having the (6S)-configuration at the C6 atom, which is typical for the “natural” folate pool.
For information related to the use refer to the product sheet of Calcium Folinate and to the general Reduced Folates chapter

 

    • Active Pharmaceutical Ingredients (API)
    • Drug
      Substance
    • Patent
    • DMF
    • CEP
    • (6S)-Calcium Folinate / Calcium Levofolinate
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    • •
    • •
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Regulatory compliance

Cerbios’ Calcium Levofolinate is complying with the specifications of the European Pharmacopoeia. In 2004, a Certificate of Suitability of the European Pharmacopoeia was granted by the European Directorate for the Quality of Medicines (EDQM). In addition an EDMF is available and updated.

Intellectual property

Method of production of the precursor 5,6,7,8-Tetrahydrofolic Acid is patent protected (EP 600 460; US 5 489 684; JP 2 588 363)

Packaging information

Calcium Levofolinate is vacuum packed in a low density polyethylene bag in a polyethylene / aluminium bag up to 4kg API. The vacuum packs are packed and shipped in cardboard boxes